Endo-periodontal zədələnmələrdə lazer terapiyasının tətbiqi

Vüsalə Mirsahib  Bayramova

doi:10.28942/ajoms.v26i1y2026.6

Abstrakt

Tədqiqatın məqsədi endodontik və periodontal zədələri olan xəstələrdə müalicəvi kombinasiyanın tətbiqi ilə əlaqəli immun dəyişiklikləri təhlil etmək idi. Tədqiqat 2020–2023-cü illər ərzində Azərbaycan Tibb Universitetinin Terapevtik stomatologiya kafedrasında aparılmışdır. İki qrup müqayisə edilmişdir: 1-ci qrup (əsas qrup, n=20) standart müalicəyə əlavə olaraq diod lazer terapiyası (Picasso Lite, İtaliya) almış, 2-ci qrup (nəzarət qrupu, n=21) isə yalnız ənənəvi müalicə ilə müalicə olunmuşdur. Əsas müalicə kursu başa çatdıqdan on iki ay sonra, tətbiq olunan müalicə üsulundan asılı olaraq proiltihabi sitokin TNF-α və immunoqlobulin IgA göstəricilərində statistik cəhətdən əhəmiyyətli fərqlər aşkar edilmiş və əsas qrupda ağız boşluğu mayesində bu göstəricilərin səviyyəsində daha nəzərəçarpacaq azalma müşahidə olunmuşdur.

Əsas mətn

28. Introduction
Endo-perio lesions might be interdependent because of the vascular and anatomic connections between the pulp and the periodontium. Endo-periodontal lesions are complex conditions that involve both the dental pulp (endodontic) and the surrounding periodontal tissues, resulting from infections, trauma, or systemic conditions. Proper diagnosis and a well-coordinated treatment plan addressing both endodontic and periodontal components are essential; early detection and appropriate therapy can significantly improve prognosis, and multidisciplinary care often yields the best results.

The problem of endo-periodontal lesions is highly relevant in modern dentistry. Endodontic and periodontal infections are difficult to distinguish and often share common clinical features, complicating diagnosis. In this regard, laser medicine is considered a promising area. Lasers have become well integrated into clinical dentistry over the past two decades, providing clinical alternatives for the management of both soft and hard tissues. The primary application of lasers in dentistry is periodontal treatment, which reduces inflammation and bleeding and promotes rapid tissue healing. As a non-surgical adjuvant therapy, laser use offers hemostasis, sterilization of periodontal pockets, biostimulation, and reduced morbidity compared with surgical methods. The aim of the study was to analyze immune changes when using a treatment complex in patients with endo-periodontal lesions.

The anatomical and functional commonality of the pulp and periodontium determines a high probability of their joint involvement in the pathological process. Communication routes between the dental pulp and periodontal tissues include dentinal tubules, lateral and additional canals, and the apical foramen. Modern studies have shown that the permeability of intact dentin is insufficient for the exchange of inflammatory mediators between the pulp and periodontal tissues. An important route for infection is the lateral and additional canals, as well as the apical foramen: waste products of microorganisms and inflammatory mediators can enter the pulp from a deep periodontal pocket and cause retrograde pulpitis, and vice versa.

29. Materials and Methods
The study, conducted from 2020 to 2023 at the Department of Therapeutic Dentistry of the Azerbaijan Medical University, included clinical, instrumental and laboratory stages. Forty-one patients with endo-periodontal lesions, not burdened with somatic pathology, were examined. Radiation diagnostic methods (orthopantomography and intraoral targeted radiographs) were performed in all patients before therapy and 6 and 12 months after completion. The groups were comparable in gender and age composition (p>0.05).

Patients were divided into two groups: Group I (main, n=20) received, alongside standard treatment, decontamination of the root canal and laser curettage with a dental diode laser (Picasso Lite); Group II (control, n=21) received standard treatment only. Root canal treatment comprised mechanical expansion with endodontic instruments and antiseptic treatment with 3% sodium hypochlorite and 17% EDTA solution. In the control group, dental deposits were removed with scaling and Gracey curettes and an ultrasound device (Piezon Master 600, EMS). Statistical analysis used the arithmetic mean (M), the Pearson χ2 test, and applied statistics programs (Microsoft Excel, Statistica for Windows v. 7.0).

30. Results and Discussion
Before treatment, baseline immune parameters did not differ significantly between groups (p=0.7238). Six months after basic combination therapy, both groups showed positive dynamics, with statistically significant intergroup differences in salivary IgA: the main group decreased to 4.46 ± 0.111 g/L versus 4.82 ± 0.118 g/L in the control group (p=0.0312). At the 12-month final stage, IgA in the main group continued to decrease to 3.43 ± 0.127 g/L, while the control group remained significantly higher at 4.17 ± 0.142 g/L (p=0.0004).

Regarding TNF-α, the reduction was significant at all stages (p=0.0001). At 6 months, control-group values decreased to 15.81 ± 0.418 pg/mL, while the main group reached 12.21 ± 0.629 pg/mL. At 12 months, TNF-α in the study group was also statistically significantly lower than the control group (p=0.0001). A directly proportional relationship was revealed at all stages between the TNF-α and periodontal index (PI), reflecting the intensity of the inflammatory process. The most pronounced positive correlation was found in the study group 6 months after treatment (r=0.38, p=0.0975).

Analyzing the periodontal PMA index, initial values did not differ significantly (p=0.6009). At 12 months, values in the main group were significantly lower than the control group (21.9 ± 0.35 vs 18.6 ± 0.27; p=0.0001). Densitometry indicated a more pronounced favorable condition of the periapical tissues in the main group, with bone density improving from 37.1 ± 1.77% to 54.2 ± 1.46% (almost 17%), versus 42.2 ± 2.48% to 49.1 ± 2.60% (about 7%) in the control group.

31. Conclusion
The method of treatment of endo-periodontal complications with a diode laser significantly reduced the focus of bone tissue destruction in the periapical region and contributed to improved oral hygiene and periodontal tissue condition. The high efficiency of the proposed combined method allows us to recommend it for wide application in practical dentistry. Further studies may assess the effectiveness of a diode laser (Picasso Lite, Italy; wavelength 810 ± 10 nm; average power ∼1.2–1.4W) in the treatment of severe forms of inflammatory-destructive periodontal disease and periapical periodontitis.

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İstinadlar

1. Moiseev D.A., Kopetsky I.S., Nikolskaya G.S., et al. The problem of primary infection in endoperiodontal lesions: a systematic review. Vol. 21(2):115–123.
2. Evans M. The endodontic-periodontal juncture: An overview of endo-perio lesions. Special Issue: Endodontics. 2023;68(1):56–65.
3. Tzanakakis E.C., Skoulas E., Pepelassi E., Koidis P., Tzoutzas I.G. The Use of Lasers in Dental Materials: A Review. Materials (Basel). 2021;14(12):3370.
4. Sachelarie L., Cristea R., Burlui E., Hurjui L.L. Laser Technology in Dentistry: From Clinical Applications to Future Innovations. Dent J (Basel). 2024;12(12):420.
5. Lazăr A.-P., Dinulescu T., Dako T., et al. Laser in periodontology: A review of the fields of applicability and therapeutic effects. Rom J Oral Rehabil. 2022;14:108.
6. Caton J.G., Armitage G., Berglundh T., et al. A new classification scheme for periodontal and periimplant diseases and conditions. J Periodontol. 2018;89(Suppl S1):S1–S8.
7. Gautam S., Galgali S.R., Sheethal H.S., Priya N.S. Pulpal changes associated with advanced periodontal disease: A histopathological study. J Oral Maxillofac Pathol. 2017;21(1):58–63.
8. Gopal K., Sangram P., Mirna G., et al. Possible Pathways of Disease Communication of the EndoPerio Lesions and their Management. Indian J Forens Med Toxicol. 2020;14(4):8415–8419.
9. Kuoch P., Bonte E. Endoperiodontal Lesions and Chicago’s New Classification of Periodontal and Peri-implant Diseases and Conditions. J Contemp Dent Pract. 2020;21(7):798–802.
10. Oktawati S., Siswanto H., Mardiana A., et al. Endodontic–periodontic lesion management: A systematic review. Medicina Clínica Práctica. 2020;3(1).
11. Tan B., Sun Q., Xiao J., Zhang L., Yan F. Pulp status of teeth in patients with chronic advanced periodontitis. Int J Clin Exp Pathol. 2020;13(4):635–641.
12. Aksel H., Serper A. A case series associated with different kinds of endoperio lesions. J Clin Exp Dent.
2014;6(1):e91–e95.
13. Dako T., Lazăr A.P., Bica C.I., Lazăr L. Endo-perio lesions: diagnosis and interdisciplinary treatment
options. Acta Stomatologica Marisiensis J. 2020;3(1):257–261.
14. Ruetters M., Kim T.S., Krisam J., El-Sayed S., ElSayed N. Effect of endodontic treatment on periodontal healing of grade 3 endo-periodontal lesions without root damage. Clin Oral Invest.
2021;25:2373–2380.
15. Giannelli M., Formigli L., Bani D. Comparative evaluation of photoablative efficacy of Er:YAG and diode laser for the treatment of gingival hyperpigmentation. J Periodontol. 2014;85(4):554–561.